For the some o hydroxylbenzenesulfonanilides,by using CNDO/2 and MMP2 method and connecting the pKa values of weak acid dissociation and the data of fasciolicidal activity; the relation between structure and activity has been studied preliminarily.

• 使用 CNDO/2和 MMP2方法 ；结合弱酸离解常数 PKa值和药物杀虫活性数据 ；初步研究了邻羟基苯磺酰苯胺类药物化合物的结构和活性的关系 .