For instance, while methylation of E-cadherin is often observed in undifferentiated carcinomas, mutation of this gene is generally associated with the progression from differentiated to undifferentiated carcinomas.

• 例如,经常观察到在未分化癌中存在甲基化的上皮细胞钙粘蛋白,这些基因的突变通常与分化癌向未分化癌进展相关联。