Finally, transgenic mice with enhanced BH4 synthesis confined to endothelial cells were unprotected against pressure overload, indicating that exogenous BH4 targeted myocytes and fibroblasts.

• 最后，增强BH4合成转基因鼠在缩窄的压力负荷下的内皮细胞没有保护作用，表明外源性的BH4对心肌和纤维化有特定的靶向作用。