Estrone was synthesized from andro 1,4 dien 3,17 dione by three steps including ketal formation, aromatization and hydrolysis. The new synthetic method of estrone was verified by amplifying and the overall yield of its amplification was 53.3%( w/w).

• 以雄甾 - 1；4-二烯 - 3；17-二酮为原料 ；经缩酮化、芳构化和水解三步反应合成雌酮 ；并对此工艺进行中试放大 ；总收率可达 5 3.；3%25。