Epidermolytic palmoplantar keratoderma, a rare autosomal dominant hereditary disease, is a keratinization disorder of palms and soles caused by mutation in the keratin 9 gene.

• 掌蹠表皮松解性角化症是一罕见体显性遗传疾病，主要是因为九号角质素基因发生突变而引起掌蹠角化异常。