Endothelin-1 contributes to increased systemic vascular resistance,vascular remoulding,left ventricular dysfunction and renal impairment in essential hypertension.

• 原发性高血压时血浆内皮素-1水平升高,可导致外周阻力增加,并且通过激活ETA和ETB受体可加重高血压病心、肾、动脉系统的损害,形成恶性循环。