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Drug loaded nanoparticle is a new type of peroral drug delivery system with tremendous advantages over traditional dosage forms. 综述近年来口服载药纳米粒的有关研究进展,着重从制备方法、表面修饰、药物释放及应用几个方面进行介绍。
The encapsulation efficiency and drug loading of triptolide-loaded poly (D,L-lactic acid) nanoparticles were analyzed by RP-HPLC and ultracentrifuge method in this study. 本文研究了反相高效液相色谱和超速冷冻离心测定雷公藤甲素聚乳酸纳米粒包封率和载药量的方法。
Drug loaded nanoparticles 载药纳米微粒
And pH gradient active drug loading method was employed to improve the DEE of INT liposome. 通过pH梯度主动载药法提高脂质体的包封率;
Thirdly, the drug loading and leasing ratio of P(NIPAm-co-AAm) and PAAc/P(NIPAm-co-AAm) gels was studied. 研究了组分配比对P(NIPAm-co-AAm)和PAAc/P(NIPAm-co-AAm)凝胶的载药和释药率的影响。
The entrapment efficiency in cationic liposomes was in the same range even if the drug loading was increased. 即使填充药量增加，带有阳离子的脂质体的包封率（仍处于相同范围）没有变化。
All these microspheres showed a restively higher drug loading efficiency at a pH value of about 7. 该制备方法具有一定的普适性，利用该方法可以制备各种无机粒子为核有机聚合物为壳的复合微球，无机粒子可以是其它金属（或其合金）或金属氧化物粒子，通过在其表面覆盖二氧化硅并进一步用硅烷偶联修饰，通过单体的沉淀聚合可以制得复合微球，壳层聚合物不限于聚（N-异丙基丙烯酰胺），也可以是其它聚合物。
Objective: To investigate the physicochemical properties and hypoglycemic effect of insulin?loaded nanoparticles (INS?NP) upon rats after oral administration. 目的：研究口服胰岛素毫微球（INS?NP）的理化性能及对大鼠的降血糖作用。
Conclusions Docetaxel-NLC with small particle sizes has improved drug loading capacity and controlled drug release properties. 结论制备的多西他赛纳米脂质载体粒径小，药物包封率高，并可实现药物控释。
Epirubicin (EPI) is a broad-spectrum antitumor antibiotic drug.To reduce the amount of administration and side effects, EPI loaded nanoparticles were prepared by dialysis. 表阿霉素(EPI)是一种广谱的抗肿瘤抗生素类药物,临床上主要剂型为注射用表阿霉素冻干粉。
A high drug loading SLN could be acquired with Compritol 888 ATO as lipid carrier, Soybean lecithin/Pluronic F_(68) (or Soybean lecithin/Tween 80) as emulsifiers. 处方研究表明采用山嵛酸甘油酯(Compritol 888 ATO)为脂质材料，豆磷脂/PluronicF-68(或豆磷脂/Tween 80)为乳化剂所得SLN载药量高、稳定性好。
The mean diameter of the prepared AmB-PBCA-NP was 94.38 nm; the mean entrapment efficiency of the particles was 82%; and the drug loading rate was 56.10%. AmB-PBCA-NP平均粒径94.;38 nm;平均包封率为82%25;载药量56
Aim To prepare rifapentine(RIF) liposomes modified by surfactants for studying their the water-solubility,drug loading effeciency,release rate and pulmonary drug delivery. 目的制备表面活性剂修饰利福喷丁(RIF)脂质体,进行该脂质体水化性能、载药量、释药速度和肺部给药研究。
Properties of mitomycin C albumin microspheres were investigated,including particle size,drug loading capacity,embedding ratio and drug sustained release property in vitro. 以药物的包封率和载药量作为制备工艺优化指标,通过正交试验得出微囊的最优处方。
OBJECTIVE：To prepare the etoposide-bovine serum albumin-microspheres (VP-BSA-MS) and to study the properties of its morphology,drug loading and release in vitro. 目的：制备依托泊苷白蛋白微球，并对其形态学性质、载药量、体外释药特性进行研究。
The orthogonal test design by adopting the standard of drug encapsulation efficiency and drug loading was applied to obtain the optimal formulation of the microcapsula. 以药物的包封率和载药量作为制备工艺优化指标,通过正交试验得出微囊的最优处方。
OBJECTIVE To prepare adriamycin bound to albumin microspheres (ADM-AMS) and to evaluate the properties of the morphology, size distribution, drug loading and trapping efficiency. 目的研究阿霉素白蛋白微球的新型制备工艺,并对其形态与大小、载药量、包封率加以考察。
When the temperature was lower than the LCST, although DgP could not form micelle, stable ILM could be formed with the drug load content as high as 45.2%. 当温度低于LCST时;虽然纯的DgP在水溶液中不会形成胶束;但是稳定的ILM依然可以形成;而且其最大载药量达到45.;2%25。
The nurse diluted the drug with saline water. 护士用生理盐水把药加以稀释。
OBJECTIVE To study the preparation of aciclovir loaded albumin microspheres (ACV BSA MS) and evaluate its morphology,drug loading and release in vitro. 目的优化阿昔洛韦白蛋白微球的制备工艺 ,并对其形态学性质、载药量、体外释药进行考察。