Dirithromycin was synthesized in overall yield of 26.5% by condensation of erythromycin with hydrazine hydrate, reduction and condensation with 2 methoxyethoxyacetaldehyde.

• 以红霉素为起始原料；经与水合肼缩合；硼氢化钠还原；然后与甲氧基乙氧基乙醛缩合；制得地红霉素；总收率26.；5%25。英文翻译；英语: