DN is the leading cause of end-stage renal disease(ESRD) in Western countries, the incidence of ESDR is rising at an alarming rate, almost 30% to 40% diabetic patients will develop DN and many will progress to ESRD.

• 在西方国家糖尿病肾病是引起终末期肾脏疾病（end-stage renal disease，ESRD）的主要原因，大约30%25-40%25的糖尿病患者会发展为糖尿病肾病，进而发展为ESRD，且ESRD的发病率在逐年上升。