DDB significantly increased the liver cytochrome P450 content, P450 isozyme 2B 1 mediated 7 pentoxyresorufin O dealkylase (PROD) activity, cytosolic glutathione (GSH) level and GSH S transferase (GST) activities.

• 联苯双酯还可增加大鼠肝脏细胞色素P4 5 0总量和胞浆GSH含量 ,诱导P4 5 0 2B1介导的PROD和GST的活性。