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- Methods Expressions of cyclin E and cyclin dependent kinases 2(cdk2)in 38 cases of lung cancer and 6 cases of normal lung tissues were examined by immunohistochemistry. 方法 :应用免疫组化方法检测细胞周期蛋白E(cyclinE)和细胞周期蛋白依赖性激酶 2 (cdk2 )在 38例肺癌和 6例正常肺组织中的表达状况。
- To study the effect of the specific cyclin dependent kinases (CDKs) inhibitor Olomoucine on apoptosis induced by low potassium and its mechanisms by using agarose gel eletrophoresis and SAPK/JNK assay kit rto measure SAPK/JNK activity. 目的 :研究化学合成的蛋白激酶抑制剂Olomoucine对低钾诱导的小脑颗粒神经元凋亡的作用及机制。 方法 :体外神经元培养、凝胶电泳和SAPK/JNK分析盒测定JNK(c -Jun氨基末端激酶 )活性。
- Cell cycle is mainly regulated by cyclin, cyclin dependent kinase(CDK) and cyclin dependentkinase inhibitor (CDKI). 细胞周期主要是由细胞周期蛋白(cyclin)，细胞周期蛋白依赖性激酶(CDKs)和CDK抑制蛋白(CDKI)来调控的。
- Protein serine theronine phosphatase inhibitor or cyclin dependent kinase( CDK) inhibitors could abolish the enhancement. 而蛋白丝氨酸苏氨酸磷酸酯酶抑制剂以及细胞周期蛋白依赖性激酶(DK)制剂可阻断该凋亡敏感性增强效应。
- In the recent years, cyclin, cyc-lin dependent kinase and cyclin dependent kinase inhibitor have important effect in cell cycle modulation. 近年来发现细胞周期素(Cyclin)、细胞周期蛋白依赖激酶(Cyclin dependent kinase，CDK)和细胞周期蛋白依赖性激酶抑制因子(Cyclin dependent kinase inhibitor，CKI)在真核生物细胞周期调控有重要作用。
- P21WAF1 is a kind of cyclin dependent kinase inhibitor, it can be bind to several kinds of cyclin/CDK compounds and arrest the cell cycle. P21~(WAF1)是一种CKI，它可与多种cyclin/CDK复合物结合，引起细胞周期阻滞。
- It is well known that cell cycle in eukaryotic cells is controlled by various complexes composed of cyclin and cyclin dependent kinase (CDK). 真核细胞周期是受细胞周期蛋白(cyclin)和细胞周期蛋白依赖激酶(cyclin dependent kinase,CDK)组成的蛋白复合体调控。
- Objective To investigate roles of cyclin dependent kinase 4 (CDK4) in nordihydroguaiaretic acid (NDGA) induced inhibitory effect on proliferation of human malignant glioma cells. 目的 探讨细胞周期蛋白依赖性蛋白激酶 4(CDK4)在去甲二氢愈创木酸 (NDGA)抑制人恶性胶质瘤细胞系SHG 44细胞增殖中的作用。
- Objective: To study the relationship between cyclin dependent kinase 4 (CDK4),PTEN protein expression and carcinogensis、progression and recurrence of endometrial carcinoma . 目的：探讨PTEN、CDK4蛋白表达与子宫内膜癌的发生、发展及复发的关系。
- Methods: The expression of cyclins dependent kinases (CDK4) in epithelial cells in the samples in 40 cases of OLP and in 10 cases of healthy controls was observed by immunohistochemical method. 方法：通过免疫组织化学方法，观察了 40例OLP上皮细胞中 CDK4（细胞周期蛋白依赖性激酶，cyclins dependent kinases）的表达状况。
- Objective To investigate the role of proliferating cell nuclear antigen (PCNA) and cyclin dependent kinase 2 (CDK2) in inhibition of vascular smooth muscle cells (VSMCs) proliferation by gax gene. 目的 研究增殖细胞核抗原 (PCNA)和细胞周期蛋白依赖性激酶 2 (CDK2 )在gax基因抑制血管平滑肌细胞 (VSMC)增殖中的作用。
- ObjectiveTo explore the abnormalities of expression of p16,retinoblastoma(RB),cyclinD1,cyclin dependent kinase 4(CDK4)genes and the relationship between these abnormalities and the cell proliferation in glioblastomas(GBMs). 目的探讨胶质母细胞瘤中p16基因、视网膜母细胞瘤基因 (retinoblastomagene,RB)、细胞周期蛋白D1(cyclinD1)基因、细胞周期蛋白依赖性激酶 4 (cyclindependentkinase 4 ,CDK4 )基因表达的异常及其与细胞增殖活性之间的关系。
- There are many factors that regulate the proliferation and differentiation of cells. The major factors include cyclin, cyclin dependent kinase (cdk) and cyclin dependent kinase inhibitor (CDKI). 调节细胞增殖和分化的因素有许多种，其中主要有细胞周期蛋白(cyclin)、细胞周期蛋白依赖性激酶(cyclin dependent kinase，cdk)和细胞周期蛋白依赖性激酶抑制因子(cyclin dependent kinase inhibitor,CDKI)。
- Purpose To investigate the roles of cyclin dependent kinase (cdk) 2 and cdk4 in the pathogenesis of benign prostatic hyperplasia (BPH) and prostatic carcinoma (PC) and their relation to PCNA. 目的：探讨细胞周期蛋白依赖性激酶cdk2和cdk4在前列腺增生（BPH）和前列腺癌（PC）的发生发展过程中作用及其与PCNA之间关系。
- Objective: To study the expression of cyclin dependant kinase 4(CDK4) protein in oral carcinogenesis. 目的：探讨CDK4蛋白在口腔粘膜癌变过程中表达的变化规律。
- cyclin dependent kinase inhibitor CK1
- cyclin dependent kinase inhibitors CDK抑制蛋白
- Cyclin dependent kinase 4 (CDK4) 细胞周期蛋白依赖性激酶4
- Cell cycle cyclin dependent kinase inhibitors(CKIs) 细胞周期
- Objective To study the role of cycline dependent kinase 4(CDK4) in the malignant transformation of human fetal lung diploid fibroblast cell(2BS) induced by silica. 目的 探讨细胞周期蛋白依赖激酶K4(CDK4)在石英致人胚肺成纤维细胞(2BS)恶性转化过程中所起的作用,为石英致癌机制提供理论依据。
