Continuous phase extraction method, solvent extraction method and reduced pressure heating method were applied to remove the residual dichloromethane in naltrexone microspheres, respectively.

• 分别采用连续相萃取法、溶剂萃取法和减压加热法去除纳曲酮微球中残留二氯甲烷,并对经减压加热法处理的微球进行体外释药试验。