Construction of gene knockout mouse, which based on gene targeting commendably simulates the phenotype of human disease and becomes a powerful mean of cleft lip and cleft palate research.

• 基于基因打靶技术建立的鼠基因敲除模型很好地模拟了人类疾病的表现型，成为研究唇腭裂的一种强有力手段。