Constitutively activated STAT3 is found in many cancers,including melanoma,breast cancer,head and neck cancer,implying the critical role of STAT3 in tumorgenesis.

• 研究表明，STAT3的持续激活与许多肿瘤和癌症相关，如黑色素瘤、骨髓瘤、急慢性白血病、头颈癌、乳腺癌、前列腺癌、小细胞癌等。