Configuration simulation through fixed aqueous layer thickness confirmed that PEG folding and less flexibility of the PEG chains of PEG_(10 000)-PHDCA niosomes were accountable for its poor stealth effects.

• 进一步通过固有水化层厚度的测定进行构型模拟表明:囊泡表面PEG发生折叠,柔韧性下降,导致其较差的隐形效果。