Conclusions: PI3K gene deletion or pharmacologic inhibition of PI3K leads to perturbations of critical innate immune responses of the lung to challenge with S. pneumoniae.

• 结论I3K基因缺失以及药物抑制PI3K干扰了在肺脏抵抗肺炎球菌时具有关键作用的先天免疫反应。