Conclusions: In this years, the drug resistance of Shigella sonnei have obviously changed in Wenzhou city.Norfloxacin, Furazolidone and Cephatrizine could be used.

• 药物呋喃唑酮、诺氟沙星、头孢三嗪可作为目前临床治疗的常用药物，但应加强对耐药性开展动态监测是十分有意义和必要的。