Conclusions The interruption of histone-to-protamine replacement reaction (HPRR) and alteration of nuclear basic proteins induced by low dose gossypol treatment might lead to infertility.

• 结论服用低剂量醋酸棉酚能阻断组蛋白-精核蛋白取代反应(HPRR)及影响精核蛋白含量，这可能是醋酸棉酚导致不育的重要原因；