Conclusions It suit to the small pedigree data.Multipoint linkage analysis can not only calculate the recombination and map distance,but also localize the disease gene to one side of the marker.

• 结论适用于小家系资料的多位点连锁分析,不仅能算出致病基因与标记的重组率和遗传距离,而且能把致病基因定位至遗传标记的一侧。