Conclusions In iodine excess, the large follicle and colloid accumulative goiter occurred in mice with manifestations of enlarged follicular cavity and increased colloid contents.

• 结论小鼠随着碘摄入量的增加，滤泡腔逐渐增大，甲状腺球蛋白含量明显增多，甲状腺发生了大滤泡胶质蓄积性肿大；