ConclusionRA can manipulate the expression level of MMP-2 and TIMP-2 mRNA in the posterior sclera and induce the elongation of ocular axis and development of eyesight as well. It may be an important factor in manipulation of eye elongation.

• 结论外源性ra能够调节巩膜MMP-2/TIMP-2的转录,并可能通过这一途径促进眼轴及屈光度的增加。