Conclusion: Single 14-membered macrolide antibiotics of sub-MIC can inhibit the formation of BBF and enhance the bactericidal action of ciprofloxacin on PA within BBF.

• 结论：低剂量十四元环大环内酯类药物能显著抑制铜绿假单胞菌生物被膜的形成，并增强环丙沙星对BBF的渗透性，从而显著增强环丙沙星对BBF内铜绿假单胞菌的清除作用。