Conclusion: Oubining can prevent vomiting induced by DDP and its mechanism is relative to the decreases of DDP, 5-HT and 5-HIAA concentrations in cerebrospinal fluid and medullary tissues.

• 结论：呕必宁对DDP所致呕吐反应具有防治作用，其机制可能与降低猫脑脊液中DDP的浓度，降低脑脊液、脑组织中5-HT、5-HIAA含量有关。