Conclusion The lidocaine-dodecanol binary eutectic system could produce high thermodynamic activity of the drug and the high driving force for transdermal permeation of lidocaine.

• 结论利多卡因-月桂醇二元低共熔混合物中的利多卡因具有较高的热力学活性,从而显著提高了利多卡因的体外透皮速率。