Conclusion The effect and WBC change of hydroxy camptothecin on chronotherapy in EAC mice had chrono-effect and changes.

• 结论 拓喜（羟基喜树碱）除了对小鼠艾氏腹水癌移植瘤抑制作用有明显的时辰差异外，对WBC的也有时辰的变化。