Conclusion Rhubarb could decrease the expression of BFGF and COX-2 in renal tissue of uric acid nephropathy rats, and then alleviate the damage of kidney and protect renal function.

• 结论：大黄能降低bFGF、COX-2在尿酸性肾病大鼠模型肾组织中的表达，从而减轻肾脏损害，保护肾功能。