Conclusion IGF-1 system was involved in the pathogenic mechanism of MND,the lack of neurotrophic support might be one of causes in leading to degeneration of spinal motor neurons.

• 结论 提示IGF-1系统参与了MND的发病机理，神经营养支持的缺乏是导致脊髓运动神经元变性的原因之一。