Conclusion Highly purified CD68+ cells can be obtained from human PBMCs as the osteoclast precursors, and mature osteoclasts can be induced from CD68+ mono/macrophages by RANKL.

• 结论人外周血单核细胞中CD68+细胞是破骨前体细胞,在RANKL在诱导下分化为成熟破骨细胞。