Commitment of hematopoietic stem cells into early B-cell lineage depends on several transcription factors, including E2A, EBA and Pax-5. In Bcl-6-/- mouse, germinal center formation was impared.

• 近年研究结果证明,转录因子E2A、EBF和Pax5在由干细胞向早期B淋巴细胞发育中起着决定性的作用。 在转录因子Bcl-6缺陷的小鼠不能形成生发中心。