Clinical trials, which assessed facial soft tissue changes with the use of either an Activator or a Bionator appliance without any surgical intervention or syndromic characteristics, were considered.

• 同时考虑到临床试验，这种试验可以评估在不经过外科手术或任何综合症特点，应用肌激动器或生物调节器后的面部软组织改变。