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The metastasis and recurrence progress of the solid tumor are highly associated with the circulating tumor cell invade cascade. 肿瘤转移及复发的过程均是一个循环肿瘤细胞定植生长的级连放大的瀑布反应。
Based on the CTC theory,detecting circulating tumor cell would help the clinician finding early metastasis or recurrence more effectively. 基于肿瘤细胞播散理论,检测循环肿瘤细胞可更早期有效发现肿瘤的早期转移和复发。
The concept of existence of circulating tumor cells(CTCs)has a history of over 100 years. 有关循环肿瘤细胞的理论已有很长时间。
We detected the T790M mutation, which confers drug resistance, in circulating tumor cells collected from patients with EGFR mutations who had received tyrosine kinase inhibitors. 在从接受酪氨酸激酶抑制剂治疗患者中收集的循环肿瘤细胞中，我们检测到了引起耐药的T790M突变，
The CTC-chip was able to reproducibly isolate circulating tumor cells in quantities that were large enough to allow molecular analyses, the authors concluded. 作者结论表示，CTC-晶片可以再现分离量化循环肿瘤细胞，而足以进行分子分析。
The study showed that the CTC-chip could reproducibly isolate circulating tumor cells in quantities that were sufficient and pure enough to allow for molecular analysis. 研究显示，CTC-晶片可以再现分离量化循环肿瘤细胞，足以适当进行分子分析；
Of the 12 patients with specimens from the primary tumor, circulating tumor cells, and plasma, genotyping of circulating cells had a sensitivity of 92%;the sensitivity for plasma genotyping was 33%. 12名原发肿瘤病患的样本中，循环肿瘤细胞、血浆与循环细胞基因型的敏感度都是92%25，血浆基因型的敏感度为33%25。
The combinational detection of circulating DNA and telomerase of circulating tumor cells is useful for the early diagnosis of tumors. 循环DNA和肿瘤细胞端粒酶的联合检测,对于肿瘤早期诊断有重要意义。
The role of detecting circulating tumor cell(CTC)in clinical cancer diagnosis and therapeutics 检测循环肿瘤细胞(CTC)在临床肿瘤诊断和治疗中的作用
Circulating tumor cell 循环瘤细胞
Keywords Non-small cell lung cancer（NSCLC）;Circulating tumor cells （CTCs）;Magnetic-activated cell separation（MACS）;Multiparameter flow Cytometry（MFCM）; 非小细胞肺癌;循环肿瘤细胞;磁性激活细胞分离;多参数流式细胞仪;
Virchow in 1851 presented a drawing of a multinucleate tumor cell. Virchow于一八五一年发表一张多核肿瘤细胞图。
Keywords Carcinoma;non small lung;Immunomagnetic seperation;Circulating tumor cells;Immunocytochemistry;Lung neoplasms; 癌;小细胞肺;磁性分离;循环癌细胞;免疫细胞化学;肺肿瘤;
VEGF also directly regulates tumor cell invasiveness. VEGF也直接调节肿瘤细胞的侵袭。
Heparanase resides in metastatic malignant tumor cell generally. 乙酰肝素酶普遍存在于转移性恶性肿瘤细胞中。
Antigen density on the tumor cell surface influences the cytotoxic sensitivity. 瘤细胞表面的抗原密度影响细胞毒的敏感性。
Size and shape changes of malignant tumor cells. 恶性肿瘤细胞大小与形态的变化。
The tumor cells infiltrated in the lipolubules. 瘤细胞浸润在脂肪小叶内，脂肪小叶间隔则不累及。
There are single tumor cells around DCIS. DCIS周围可见单个肿瘤细胞。
Fig.3 EPSPC tumor cell containing dense-electron granules and small lumen. 图3EPSPC肿瘤细胞内的密电子颗粒及小腺腔。