Changes of the expression of VEGF and its receptor Flk-1 in lungs of premature rats exposed to 60% oxygen may contribute to the development of BPD.

• 60%25氧暴露可引起早产大鼠肺部VEGF及其受体Flk-1表达下降,可能是引起肺微血管发育障碍及肺泡化进程受阻,进而导致新型BPD发生的重要因素。