Cell-cycle dysregulation is a hallmark of tumor cells.The ability of normal cells to undergo cell-cycle arrest after damage to DNA is crucial for the maintenance of genomic integrity.

• 肿瘤细胞具有细胞周期失调的共同特点,而正常细胞脱氧核糖核酸在受到损伤后能够发生细胞周期阻滞以及时修复损伤,即通过细胞关卡调控,这是保持基因组稳定的关键事件。