Canine distemper virus has been a cause of morbidity and mortality in many animals all over the world.Distemper goes through about four centuries from it was isolated firstly to today.

• 摘要犬瘟热病毒引起多种动物的烈性瘟热病，遍及全世界，从最初的瘟热病毒的分离，到现在犬瘟热经历了近4个世纪的传播衍化过程。