CFC syndrome and CS can be distinguished from NS by the presence of ectodermal abnormalities, mental retardation and a lack of familial cases.

• 心脏-脸-皮肤徵候群及科斯特洛徵候群二者均具有外胚层的异常，智障，及缺乏家族案例，这些可以和努男徵候群区别；