CD44V6 may play an important role in promoting HCC cells to adhere to vascular endothelium and base membranes and may affect the distribution, polymerization and depolymerization of actin in HCC cells and facilitate HCC cell metastasis.

• CD44V6变异体能促进大肠癌细胞与血管内皮细胞及基底膜的粘附和浸润，并影响细胞骨架蛋白的构型和分布，增强肿瘤细胞的运动能力，促进肿瘤转移的发生