CD44ASODN can down-regulate the expression of CD44 mRNA and protein, inhibit MGC80-3 cell pro liferation and promote apoptosis induced by Fas mAb.

• CD44反义寡核苷酸通过抑MGC80-3细胞CD44m RNA和蛋白表达；抑制MGC80-3细胞的增生；增高细胞表面Fas的表达及MGC80-3细胞对FasmAb诱导凋亡的敏感性；逆转胃癌细胞的免疫逃逸作用.