C5L2 plays a role in the disease involved in anaphyltoxin C5a and has significance for the study of G protein coupled receptor. C5L2 is also a valuable tool for studying the biological activities of C5a and C5a des Arg74.

• 作为过敏毒素受体,C5L2在过敏毒素C5a参与的相关疾病,如脓毒症(sepsis)、急性肺损伤(ALI)、急性呼吸窘迫综合征(ARDS)等的发生、发展以及对G蛋白偶联受体的研究都具有重要的意义。