By using lysozyme, RNase A and protein disulfide isomerase (PDI) as model proteins, we present a hypothesis that protein cross-linking can be accomplished in three concerted steps: (1) a change in protein conformation;

• 我们以溶菌酶、核糖核酸酶A和蛋白质二硫键异构酶为模型在体外详细地研究了异肽键，提出了解释异肽键形成机理的假说：1)蛋白质发生构象变化包括二级结构的改变；