By using berberine,baicalin and the weight of the extract as qualitycontrol criteria, traditional extraction process of coptidis decoction fordetoxification(CDD) was optimized with the aid of orthogonal design.

• 本研究采用正交试验设计方法，以浸膏量、盐酸小檗碱和黄芩苷含量为指标，优化了黄连解毒汤水煎醇沉工艺。