By reviewing related literature,we realized that in the head and neck region, over-expression of OPN was found only in dysplastic and squamous cell carcinoma(SCC) and not in normal mucosa.

• 大量的文献报道,OPN在头颈部的正常黏膜中无表达,而在发育不良和鳞状细胞癌的组织中呈阳性表达,且表达水平与肿瘤的转移和恶性程度有关。