Both of them are localized within the endoplasmic reticulum(ER) and possess ATP-binding sites. Envidence has shown that GRPs function as molecular chaperones by assisting in the proper folding and assembly of proteins within the ER.

• 同时他们又是分布在内质网(Endoplasmic Reticulum ER)腔内的分子伴侣，具有弱的ATP酶活性，与ATP结合后可以协助新生蛋白质的转位、折叠以及寡聚蛋白的组装。