Bordetella pertussis toxin S1 mutant was successfully expressed and purified,which laid a molecular immunological foundation of developing candidate antigen of pertussis vaccine.

• 成功表达并纯化了百日咳毒素S1亚单位突变体,为研制百日咳疫苗候补抗原的相关分子免疫学研究奠定了基础。