Begin with metformin unless eidence or risk of renal impairment, titrating the dose oer early weeks to minimize discontinuation due to gastro-intestinal intolerance.

• 如果没有肾脏受损或有受损危险的情况下，起始应用二甲双胍治疗。在最初的几周调整剂量，将由于胃肠道不适引起的停药减小到最少。