BackgroundRenal interstitial fibrosis (RIF) is the final common pathway of chronic kidney disease (CKD) to the end stage renal failure (ESRF), characterized with the tubular epithelial cell depletion and expanding of extracelluar matrix (ECM).

• 肾间质纤维化(RIF)以肾小管上皮细胞丢失和肾脏间质中细胞外基质(ECM)过度沉积为特征，是各种慢性肾脏疾病(CKD)进展到终末期肾衰竭(ESRF)的最终共同途径。 RIF病变程度比肾小球病变更能反映肾功能损害情况。