BHT could induce apoptosis to pulmonary macrophage in the perfusate of isolate perfused rat lung as examined by the technology of PI fluorescence stain and comet assay.

• 结论亚急性BHT大剂量染毒可造成大鼠肺、肝等脏器功能性和器质性损伤，BHT可诱发肺巨噬细胞凋亡的产生。