As to tumor cell with defect in apoptosis, autophagy limits its necrosis and inflammation, reduces the damage of genome and prolongs its survival under metabolic stress.

• 近期的研究发现，自噬作用在肿瘤的形成中亦起着重要作用。具有凋亡缺陷的肿瘤细胞可以凭借自噬作用减少坏死和炎症反应，以减轻代谢压力下的基因损伤,维持长久生存。