As a result, we found that the C-terminal fragment of HBO1 (histone acetyltransferase binding to ORC1), an MYST family histone acetyltransferase, interacted with CDK11p58 in yeast.

• 我们进一步研究发现在体外HAT检测反应体系中直接加入原核表达的CDK11p58纯化蛋白，能显著促进HBO1对的HAT活性；