As 2 O 3 could obviously inhibit the expression of Evi_1mRNA and activate JNK signal transduction pathway,which may be a possible mechanism of As 2 O 3 inducing apoptosis in K562cells.

• As2O3通过抑制K562细胞Evi-1表达,从而激活JNK信号传导途径,促进细胞凋亡,这可能是As2O3促进K562细胞凋亡的机制之一。