As 2 O 3 could down_regulate significantly the expression of Evi_1mRNA and up_regulate JNK protein in K562cells in time_ and dose_dependent manner.

• 在此过程中K562细胞的Evi-1基因表达下调,JNK蛋白表达增多,两者跟As2O3浓度存在剂量-时间关系。